Amitriptyline For Migraine Prevention
In fact, according to the 2012 guidelines for preventing episodic migraines (defined as headaches that occur fewer than 15 times per month) established by the American Headache Society (AHS) and the American Academy of Neurology (AAN), amitriptyline is a level B medication for migraine prophylaxis, meaning it’s regarded as “probably effective.” How It Works As an antidepressant, amitriptyline increases the levels of neurotransmitters in the brain that affect mood and well-being—specifically, serotonin and norepinephrine....